Drug interactions
Choline magnesium trisalicylate + Irbesartan
Severity: Moderate
Choline magnesium trisalicylate and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at anti-inflammatory doses can diminish irbesartan's antihypertensive effect and impair renal function, especially in elderly or volume-depleted patients. Potassium may also rise.
What this interaction means in plain words
Choline magnesium trisalicylate and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, opposing angiotensin receptor blockade.
What to do
Ensure adequate hydration and monitor blood pressure, creatinine and potassium. Use the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Irbesartan?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at anti-inflammatory doses can diminish irbesartan's antihypertensive effect and impair renal function, especially in elderly or volume-depleted patients. Potassium may also rise.
How serious is the interaction between Choline magnesium trisalicylate and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, creatinine and potassium. Use the lowest effective salicylate dose.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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