Drug interactions
Choline magnesium trisalicylate + Ketoprofen
Severity: Moderate
Choline magnesium trisalicylate and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining ketoprofen with a salicylate increases the risk of gastrointestinal irritation and bleeding and adds to renal risk. Little additional analgesic benefit is expected.
What this interaction means in plain words
Choline magnesium trisalicylate and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive COX inhibition reduces gastroprotective prostaglandins and platelet function; nonacetylated salicylates have weaker antiplatelet effect.
What to do
Avoid using the two together; choose one agent at the lowest effective dose. Monitor for gastrointestinal bleeding and renal function if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Ketoprofen?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining ketoprofen with a salicylate increases the risk of gastrointestinal irritation and bleeding and adds to renal risk. Little additional analgesic benefit is expected.
How serious is the interaction between Choline magnesium trisalicylate and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two together; choose one agent at the lowest effective dose. Monitor for gastrointestinal bleeding and renal function if combined.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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