Drug interactions
Choline magnesium trisalicylate + Levofloxacin
Severity: Moderate
Choline magnesium trisalicylate and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates carry little evidence of a seizure interaction with levofloxacin, although NSAID co-use is flagged for CNS excitation. The magnesium content may also reduce levofloxacin absorption when taken together orally.
What this interaction means in plain words
Choline magnesium trisalicylate and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Magnesium chelates levofloxacin in the gut, reducing absorption, and a theoretical additive GABA-antagonist effect is possible.
What to do
Give levofloxacin at least 2 hours before or after this product. Monitor for CNS symptoms in patients with seizure risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Levofloxacin?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates carry little evidence of a seizure interaction with levofloxacin, although NSAID co-use is flagged for CNS excitation. The magnesium content may also reduce levofloxacin absorption when taken together orally.
How serious is the interaction between Choline magnesium trisalicylate and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give levofloxacin at least 2 hours before or after this product. Monitor for CNS symptoms in patients with seizure risk.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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