Drug interactions
Choline magnesium trisalicylate + Mesalamine
Severity: Moderate
Choline magnesium trisalicylate and Mesalamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesalamine is a 5-aminosalicylate that can rarely cause interstitial nephritis, and full-dose salicylates can also affect renal function, especially with dehydration or existing kidney disease. Using them together may add to the risk of kidney injury.
What this interaction means in plain words
Choline magnesium trisalicylate and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potential renal toxicity, including prostaglandin-related reduction in renal perfusion and interstitial nephritis.
What to do
Check serum creatinine and urinalysis at baseline and periodically during combined use, and keep the patient well hydrated. Stop or reduce the salicylate if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mesalamine
Frequently asked questions
Can I take Choline magnesium trisalicylate with Mesalamine?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mesalamine is a 5-aminosalicylate that can rarely cause interstitial nephritis, and full-dose salicylates can also affect renal function, especially with dehydration or existing kidney disease. Using them together may add to the risk of kidney injury.
How serious is the interaction between Choline magnesium trisalicylate and Mesalamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum creatinine and urinalysis at baseline and periodically during combined use, and keep the patient well hydrated. Stop or reduce the salicylate if renal function declines.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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