Drug interactions
Choline magnesium trisalicylate + Pemetrexed
Severity: Moderate
Choline magnesium trisalicylate and Pemetrexed: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs and non-acetylated salicylates can reduce renal clearance of pemetrexed, raising its exposure. This increases the risk of myelosuppression, mucositis and renal toxicity, especially in patients with mild to moderate renal impairment.
What this interaction means in plain words
Choline magnesium trisalicylate and Pemetrexed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced renal elimination of pemetrexed through effects on renal prostaglandins and possible competition for tubular secretion.
What to do
In patients with creatinine clearance below 80 mL/min, avoid the salicylate or hold it for several days before, on the day of, and for 2 days after pemetrexed. Monitor blood counts and renal function if coadministration is necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pemetrexed
Frequently asked questions
Can I take Choline magnesium trisalicylate with Pemetrexed?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Pemetrexed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs and non-acetylated salicylates can reduce renal clearance of pemetrexed, raising its exposure. This increases the risk of myelosuppression, mucositis and renal toxicity, especially in patients with mild to moderate renal impairment.
How serious is the interaction between Choline magnesium trisalicylate and Pemetrexed?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients with creatinine clearance below 80 mL/min, avoid the salicylate or hold it for several days before, on the day of, and for 2 days after pemetrexed. Monitor blood counts and renal function if coadministration is necessary.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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