Drug interactions
Choline magnesium trisalicylate + Pralatrexate
Severity: Moderate
Choline magnesium trisalicylate and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can reduce renal clearance of pralatrexate, raising its exposure and toxicity such as mucositis and myelosuppression.
What this interaction means in plain words
Choline magnesium trisalicylate and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion reduces pralatrexate clearance.
What to do
Use paracetamol instead where possible. If used together, monitor for mucositis, blood counts and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pralatrexate
Frequently asked questions
Can I take Choline magnesium trisalicylate with Pralatrexate?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates can reduce renal clearance of pralatrexate, raising its exposure and toxicity such as mucositis and myelosuppression.
How serious is the interaction between Choline magnesium trisalicylate and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use paracetamol instead where possible. If used together, monitor for mucositis, blood counts and renal function.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
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