Drug interactions
Choline magnesium trisalicylate + Prednisone
Severity: Moderate
Choline magnesium trisalicylate and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates combined with corticosteroids increase the risk of gastrointestinal ulceration and bleeding. Corticosteroids may also lower salicylate levels, which can rise when the steroid is withdrawn.
What this interaction means in plain words
Choline magnesium trisalicylate and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury; corticosteroids also increase renal clearance of salicylate.
What to do
Consider proton pump inhibitor gastroprotection and monitor for GI bleeding. Check salicylate levels or toxicity signs when prednisone is tapered or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Prednisone?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates combined with corticosteroids increase the risk of gastrointestinal ulceration and bleeding. Corticosteroids may also lower salicylate levels, which can rise when the steroid is withdrawn.
How serious is the interaction between Choline magnesium trisalicylate and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider proton pump inhibitor gastroprotection and monitor for GI bleeding. Check salicylate levels or toxicity signs when prednisone is tapered or stopped.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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