Drug interactions
Choline magnesium trisalicylate + Probenecid
Severity: Moderate
Choline magnesium trisalicylate and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates antagonize the uricosuric effect of probenecid, particularly at analgesic doses, reducing its urate-lowering efficacy. Gout control may deteriorate.
What this interaction means in plain words
Choline magnesium trisalicylate and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate competes for renal tubular transport and inhibits probenecid-mediated urate excretion.
What to do
Avoid salicylates in patients taking probenecid for gout; use another analgesic such as paracetamol, and monitor serum uric acid if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Probenecid?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates antagonize the uricosuric effect of probenecid, particularly at analgesic doses, reducing its urate-lowering efficacy. Gout control may deteriorate.
How serious is the interaction between Choline magnesium trisalicylate and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid salicylates in patients taking probenecid for gout; use another analgesic such as paracetamol, and monitor serum uric acid if combined.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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