Drug interactions
Choline magnesium trisalicylate + Sertraline
Severity: Moderate
Choline magnesium trisalicylate and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline impairs platelet function and salicylates add to bleeding risk, increasing the chance of gastrointestinal bleeding. Non-acetylated salicylates have weaker platelet effects than aspirin, so the risk may be lower.
What this interaction means in plain words
Choline magnesium trisalicylate and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effect on hemostasis from SSRI platelet serotonin depletion and salicylate effects with mucosal irritation.
What to do
Monitor for signs of GI bleeding and consider a proton pump inhibitor in high-risk patients. Use the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Choline magnesium trisalicylate and Sertraline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Sertraline?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline impairs platelet function and salicylates add to bleeding risk, increasing the chance of gastrointestinal bleeding. Non-acetylated salicylates have weaker platelet effects than aspirin, so the risk may be lower.
How serious is the interaction between Choline magnesium trisalicylate and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and consider a proton pump inhibitor in high-risk patients. Use the lowest effective salicylate dose.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
