Drug interactions
Choline magnesium trisalicylate + Sulindac
Severity: Major
Choline magnesium trisalicylate and Sulindac: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a salicylate with sulindac increases the risk of gastrointestinal irritation, ulceration and bleeding without added therapeutic benefit. Salicylates may also lower NSAID concentrations and add to renal toxicity risk.
What this interaction means in plain words
Choline magnesium trisalicylate and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive cyclooxygenase inhibition with impaired platelet function and gastric mucosal protection.
What to do
Avoid using two NSAID-type agents together and use one agent at the lowest effective dose. If both are needed, add gastroprotection and monitor for GI bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Sulindac?
MediHelp rates the interaction as major. Choline magnesium trisalicylate and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a salicylate with sulindac increases the risk of gastrointestinal irritation, ulceration and bleeding without added therapeutic benefit. Salicylates may also lower NSAID concentrations and add to renal toxicity risk.
How serious is the interaction between Choline magnesium trisalicylate and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two NSAID-type agents together and use one agent at the lowest effective dose. If both are needed, add gastroprotection and monitor for GI bleeding and renal function.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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