Drug interactions
Choline magnesium trisalicylate + Tolbutamide
Severity: Moderate
Choline magnesium trisalicylate and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can potentiate sulfonylurea effect and cause hypoglycemia, especially at the higher doses used for anti-inflammatory therapy.
What this interaction means in plain words
Choline magnesium trisalicylate and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate displaces sulfonylureas from plasma proteins and has intrinsic glucose-lowering activity.
What to do
Monitor blood glucose when starting, stopping or changing the salicylate dose. Lower the tolbutamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Choline magnesium trisalicylate with Tolbutamide?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates can potentiate sulfonylurea effect and cause hypoglycemia, especially at the higher doses used for anti-inflammatory therapy.
How serious is the interaction between Choline magnesium trisalicylate and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, stopping or changing the salicylate dose. Lower the tolbutamide dose if hypoglycemia occurs.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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