Drug interactions
Chromium + Glibenclamide
Severity: Minor
Chromium and Glibenclamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chromium supplements may modestly improve insulin sensitivity, which could add to the glucose-lowering effect of glyburide. The effect is generally small, but hypoglycemia is possible in susceptible patients.
What this interaction means in plain words
Chromium and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chromium belongs to Gastrointestinal Tract; Glibenclamide belongs to Endocrine.
Why it happens
Additive glucose lowering through possible enhancement of insulin sensitivity by chromium.
What to do
Monitor blood glucose when chromium supplements are started. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Chromium
- Chromium + Omadacycline Moderate
- Chromium + Sarecycline Moderate
- Acarbose + Chromium Minor
- Acetylsalicylic acid + Chromium Minor
- Alogliptin-metformin + Chromium Minor
- Alogliptin-pioglitazone + Chromium Minor
Frequently asked questions
Can I take Chromium with Glibenclamide?
MediHelp rates the interaction as minor. Chromium and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chromium supplements may modestly improve insulin sensitivity, which could add to the glucose-lowering effect of glyburide. The effect is generally small, but hypoglycemia is possible in susceptible patients.
How serious is the interaction between Chromium and Glibenclamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when chromium supplements are started. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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