Drug interactions
Ciclesonide inhaled + Mifepristone
Severity: Moderate
Ciclesonide inhaled and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase systemic exposure to ciclesonide's active metabolite. Mifepristone also antagonizes glucocorticoid receptors, which may blunt the corticosteroid effect.
What this interaction means in plain words
Ciclesonide inhaled and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition raises corticosteroid exposure, while glucocorticoid receptor antagonism opposes its effect.
What to do
Monitor asthma control and signs of corticosteroid excess. Adjust the inhaled steroid dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Ciclesonide inhaled with Mifepristone?
MediHelp rates the interaction as moderate. Ciclesonide inhaled and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase systemic exposure to ciclesonide's active metabolite. Mifepristone also antagonizes glucocorticoid receptors, which may blunt the corticosteroid effect.
How serious is the interaction between Ciclesonide inhaled and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma control and signs of corticosteroid excess. Adjust the inhaled steroid dose according to response.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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