Drug interactions
Cigarette smoking + Cilostazol
Severity: Minor
Cigarette smoking and Cilostazol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Smoking induces CYP1A2 and may modestly lower cilostazol exposure. Labeling reports reduced plasma levels in smokers, though the effect on clinical outcome is small.
What this interaction means in plain words
Cigarette smoking and Cilostazol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of hepatic CYP enzymes by tobacco smoke increases cilostazol metabolism.
What to do
No dose adjustment is routinely needed. Encourage smoking cessation, which benefits claudication, and reassess response if smoking status changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cilostazol
Frequently asked questions
Can I take Cigarette smoking with Cilostazol?
MediHelp rates the interaction as minor. Cigarette smoking and Cilostazol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Smoking induces CYP1A2 and may modestly lower cilostazol exposure. Labeling reports reduced plasma levels in smokers, though the effect on clinical outcome is small.
How serious is the interaction between Cigarette smoking and Cilostazol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed. Encourage smoking cessation, which benefits claudication, and reassess response if smoking status changes.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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