Drug interactions
Cigarette smoking + Thioridazine
Severity: Minor
Cigarette smoking and Thioridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tobacco smoke induces CYP1A2 and may lower phenothiazine concentrations, which can reduce effect in smokers. Stopping smoking may lead to rising levels and increased adverse effects.
What this interaction means in plain words
Cigarette smoking and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of hepatic metabolism by constituents of tobacco smoke.
What to do
Monitor clinical response and adverse effects when smoking status changes, and adjust the thioridazine dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Cigarette smoking with Thioridazine?
MediHelp rates the interaction as minor. Cigarette smoking and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tobacco smoke induces CYP1A2 and may lower phenothiazine concentrations, which can reduce effect in smokers. Stopping smoking may lead to rising levels and increased adverse effects.
How serious is the interaction between Cigarette smoking and Thioridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adverse effects when smoking status changes, and adjust the thioridazine dose accordingly.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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