Drug interactions
Cilostazol + Citalopram
Severity: Moderate
Cilostazol and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs reduce platelet serotonin uptake and increase bleeding risk, which may be compounded by the antiplatelet effect of cilostazol. Bleeding is mostly gastrointestinal or cutaneous.
What this interaction means in plain words
Cilostazol and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Citalopram belongs to Central Nervous System.
Why it happens
Additive impairment of platelet function by serotonin reuptake inhibition and PDE3 inhibition.
What to do
Monitor for bleeding and bruising; consider gastroprotection in patients at high risk of gastrointestinal bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Cilostazol with Citalopram?
MediHelp rates the interaction as moderate. Cilostazol and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs reduce platelet serotonin uptake and increase bleeding risk, which may be compounded by the antiplatelet effect of cilostazol. Bleeding is mostly gastrointestinal or cutaneous.
How serious is the interaction between Cilostazol and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and bruising; consider gastroprotection in patients at high risk of gastrointestinal bleeding.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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