Drug interactions
Cilostazol + Conivaptan
Severity: Moderate
Cilostazol and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a strong CYP3A4 inhibitor and can raise cilostazol exposure. This increases the risk of cilostazol adverse effects such as tachycardia, palpitations and headache.
What this interaction means in plain words
Cilostazol and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated cilostazol metabolism by conivaptan.
What to do
Reduce cilostazol to 50 mg twice daily during conivaptan therapy, as labeling advises for strong CYP3A4 inhibitors, and monitor heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cilostazol and Conivaptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Conivaptan?
MediHelp rates the interaction as moderate. Cilostazol and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a strong CYP3A4 inhibitor and can raise cilostazol exposure. This increases the risk of cilostazol adverse effects such as tachycardia, palpitations and headache.
How serious is the interaction between Cilostazol and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce cilostazol to 50 mg twice daily during conivaptan therapy, as labeling advises for strong CYP3A4 inhibitors, and monitor heart rate.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
