Drug interactions
Cilostazol + Dabrafenib
Severity: Moderate
Cilostazol and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower cilostazol concentrations, which could reduce its therapeutic effect. The magnitude has not been specifically defined.
What this interaction means in plain words
Cilostazol and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Dabrafenib belongs to Oncology.
Why it happens
CYP3A4 induction by dabrafenib increases cilostazol metabolism.
What to do
Monitor claudication symptoms for loss of benefit. Consider an alternative therapy if cilostazol becomes ineffective.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Dabrafenib
Frequently asked questions
Can I take Cilostazol with Dabrafenib?
MediHelp rates the interaction as moderate. Cilostazol and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower cilostazol concentrations, which could reduce its therapeutic effect. The magnitude has not been specifically defined.
How serious is the interaction between Cilostazol and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor claudication symptoms for loss of benefit. Consider an alternative therapy if cilostazol becomes ineffective.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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