Drug interactions
Cilostazol + Dexamethasone-tobramycin
Severity: Minor
Cilostazol and Dexamethasone-tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a CYP3A4 inducer and may lower cilostazol exposure, potentially weakening its effect. The induction is modest at low systemic exposures and larger with systemic dosing.
What this interaction means in plain words
Cilostazol and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cilostazol belongs to Cardiovascular; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 by dexamethasone increases cilostazol metabolism.
What to do
Monitor claudication symptom response when systemic dexamethasone is used long term. No empiric cilostazol dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Dexamethasone-tobramycin?
MediHelp rates the interaction as minor. Cilostazol and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone is a CYP3A4 inducer and may lower cilostazol exposure, potentially weakening its effect. The induction is modest at low systemic exposures and larger with systemic dosing.
How serious is the interaction between Cilostazol and Dexamethasone-tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor claudication symptom response when systemic dexamethasone is used long term. No empiric cilostazol dose change is needed.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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