Drug interactions
Cilostazol + Fosamprenavir
Severity: Moderate
Cilostazol and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, particularly when boosted with ritonavir. This may raise cilostazol levels and the risk of tachycardia and headache.
What this interaction means in plain words
Cilostazol and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by amprenavir (with or without ritonavir) reduces cilostazol clearance.
What to do
Consider cilostazol 50 mg twice daily and monitor heart rate and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Fosamprenavir?
MediHelp rates the interaction as moderate. Cilostazol and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, particularly when boosted with ritonavir. This may raise cilostazol levels and the risk of tachycardia and headache.
How serious is the interaction between Cilostazol and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider cilostazol 50 mg twice daily and monitor heart rate and adverse effects.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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