Drug interactions
Cilostazol + Indinavir
Severity: Moderate
Cilostazol and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a potent CYP3A4 inhibitor and can substantially raise cilostazol exposure. This increases the risk of tachycardia, headache and other dose-related effects.
What this interaction means in plain words
Cilostazol and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition by indinavir reduces cilostazol metabolism.
What to do
Reduce cilostazol to 50 mg twice daily and monitor heart rate and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Indinavir?
MediHelp rates the interaction as moderate. Cilostazol and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a potent CYP3A4 inhibitor and can substantially raise cilostazol exposure. This increases the risk of tachycardia, headache and other dose-related effects.
How serious is the interaction between Cilostazol and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce cilostazol to 50 mg twice daily and monitor heart rate and tolerability.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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