Drug interactions
Cilostazol + Isoniazid
Severity: Moderate
Cilostazol and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cilostazol is metabolized by CYP3A4 and CYP2C19, both of which isoniazid can inhibit. Raised cilostazol and active metabolite levels may cause headache, tachycardia, palpitations and hypotension.
What this interaction means in plain words
Cilostazol and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibition of CYP2C19 and CYP3A4 reduces cilostazol clearance.
What to do
Monitor for cilostazol adverse effects and consider reducing the dose to 50 mg twice daily. Avoid use in patients with heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Isoniazid?
MediHelp rates the interaction as moderate. Cilostazol and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cilostazol is metabolized by CYP3A4 and CYP2C19, both of which isoniazid can inhibit. Raised cilostazol and active metabolite levels may cause headache, tachycardia, palpitations and hypotension.
How serious is the interaction between Cilostazol and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cilostazol adverse effects and consider reducing the dose to 50 mg twice daily. Avoid use in patients with heart failure.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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