Drug interactions
Cilostazol + Quinupristin / dalfopristin
Severity: Moderate
Cilostazol and Quinupristin / dalfopristin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin may increase cilostazol concentrations, raising the risk of headache, palpitations, tachycardia and diarrhea.
What this interaction means in plain words
Cilostazol and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, decreasing cilostazol metabolism.
What to do
Monitor for cilostazol adverse effects and consider reducing the dose to 50 mg twice daily during the antibiotic course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Cilostazol and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin may increase cilostazol concentrations, raising the risk of headache, palpitations, tachycardia and diarrhea.
How serious is the interaction between Cilostazol and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cilostazol adverse effects and consider reducing the dose to 50 mg twice daily during the antibiotic course.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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