Drug interactions
Cilostazol + Rabeprazole
Severity: Minor
Cilostazol and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cilostazol and its active metabolite are cleared partly by CYP2C19, and PPIs such as omeprazole raise exposure to the active metabolite. Rabeprazole is metabolized mostly non-enzymatically and is a weak CYP2C19 inhibitor, so the effect is likely small.
What this interaction means in plain words
Cilostazol and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cilostazol belongs to Cardiovascular; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Weak CYP2C19 inhibition may slightly reduce clearance of cilostazol's active metabolite.
What to do
No routine dose change is needed; monitor for headache, tachycardia or palpitations, and consider cilostazol dose reduction if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Rabeprazole?
MediHelp rates the interaction as minor. Cilostazol and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cilostazol and its active metabolite are cleared partly by CYP2C19, and PPIs such as omeprazole raise exposure to the active metabolite. Rabeprazole is metabolized mostly non-enzymatically and is a weak CYP2C19 inhibitor, so the effect is likely small.
How serious is the interaction between Cilostazol and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for headache, tachycardia or palpitations, and consider cilostazol dose reduction if they occur.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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