Drug interactions
Cilostazol + Selumetinib
Severity: Moderate
Cilostazol and Selumetinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cilostazol inhibits platelet aggregation, and selumetinib carries a labeled bleeding risk with antiplatelet agents or vitamin K antagonists. Combined use may raise the likelihood of bleeding.
What this interaction means in plain words
Cilostazol and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Selumetinib belongs to Oncology.
Why it happens
Additive pharmacodynamic effects on hemostasis; cilostazol inhibits platelets while selumetinib is associated with bleeding events.
What to do
Monitor for signs of bleeding and check blood counts. Reassess the need for cilostazol if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Selumetinib
Frequently asked questions
Can I take Cilostazol with Selumetinib?
MediHelp rates the interaction as moderate. Cilostazol and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cilostazol inhibits platelet aggregation, and selumetinib carries a labeled bleeding risk with antiplatelet agents or vitamin K antagonists. Combined use may raise the likelihood of bleeding.
How serious is the interaction between Cilostazol and Selumetinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check blood counts. Reassess the need for cilostazol if bleeding occurs.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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