Drug interactions
Cilostazol + Vorapaxar
Severity: Major
Cilostazol and Vorapaxar: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs inhibit platelet function, so combining them can increase bleeding risk. Vorapaxar is also contraindicated in patients with prior stroke, TIA or intracranial hemorrhage.
What this interaction means in plain words
Cilostazol and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive antiplatelet effects: vorapaxar blocks PAR-1 thrombin receptors while cilostazol inhibits PDE3 in platelets.
What to do
Avoid combining unless benefit clearly outweighs risk, and monitor closely for bleeding and hemoglobin changes. Do not use in patients with prior intracranial hemorrhage.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cilostazol and Vorapaxar, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Vorapaxar?
MediHelp rates the interaction as major. Cilostazol and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs inhibit platelet function, so combining them can increase bleeding risk. Vorapaxar is also contraindicated in patients with prior stroke, TIA or intracranial hemorrhage.
How serious is the interaction between Cilostazol and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless benefit clearly outweighs risk, and monitor closely for bleeding and hemoglobin changes. Do not use in patients with prior intracranial hemorrhage.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
