Drug interactions
Cimetidine + Dienogest / estradiol valerate
Severity: Minor
Cimetidine and Dienogest / estradiol valerate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both dienogest and estradiol are partly metabolized by CYP3A4, so cimetidine may slightly increase hormone levels. This could cause estrogenic or progestogenic adverse effects such as breast tenderness, nausea or irregular bleeding.
What this interaction means in plain words
Cimetidine and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cimetidine weakly inhibits CYP3A4 metabolism of dienogest and estradiol.
What to do
No dose change is usually required; counsel the patient to report breast tenderness, headache or bleeding changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cimetidine and Dienogest / estradiol valerate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Dienogest / estradiol valerate?
MediHelp rates the interaction as minor. Cimetidine and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both dienogest and estradiol are partly metabolized by CYP3A4, so cimetidine may slightly increase hormone levels. This could cause estrogenic or progestogenic adverse effects such as breast tenderness, nausea or irregular bleeding.
How serious is the interaction between Cimetidine and Dienogest / estradiol valerate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; counsel the patient to report breast tenderness, headache or bleeding changes.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
