Drug interactions
Cimetidine + Doxorubicin liposomal
Severity: Minor
Cimetidine and Doxorubicin liposomal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin metabolism involves hepatic enzymes, and cimetidine may modestly raise exposure. Liposomal formulation has distinct kinetics, so any effect is uncertain and likely small.
What this interaction means in plain words
Cimetidine and Doxorubicin liposomal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cimetidine may weakly inhibit hepatic metabolism of doxorubicin; the effect on the liposomal form is not well established.
What to do
No dose adjustment is routinely needed; monitor blood counts and cardiac function as standard.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Doxorubicin liposomal?
MediHelp rates the interaction as minor. Cimetidine and Doxorubicin liposomal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin metabolism involves hepatic enzymes, and cimetidine may modestly raise exposure. Liposomal formulation has distinct kinetics, so any effect is uncertain and likely small.
How serious is the interaction between Cimetidine and Doxorubicin liposomal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed; monitor blood counts and cardiac function as standard.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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