Drug interactions
Cimetidine + Estrogens conjugated synthetic
Severity: Minor
Cimetidine and Estrogens conjugated synthetic: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may modestly increase estrogen exposure. This could heighten estrogenic adverse effects such as breast tenderness, fluid retention or nausea.
What this interaction means in plain words
Cimetidine and Estrogens conjugated synthetic have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cimetidine inhibits CYP3A4 and other CYPs involved in estrogen metabolism, which may reduce estrogen clearance.
What to do
No routine change is needed; review estrogen-related adverse effects and adjust the estrogen dose if they emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Estrogens conjugated synthetic?
MediHelp rates the interaction as minor. Cimetidine and Estrogens conjugated synthetic have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may modestly increase estrogen exposure. This could heighten estrogenic adverse effects such as breast tenderness, fluid retention or nausea.
How serious is the interaction between Cimetidine and Estrogens conjugated synthetic?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; review estrogen-related adverse effects and adjust the estrogen dose if they emerge.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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