Drug interactions
Cimetidine + Estrogens esterified
Severity: Minor
Cimetidine and Estrogens esterified: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens are partly metabolized by CYP3A4, so cimetidine may slightly raise estrogen levels. Clinical impact is typically small and may show as breast tenderness or nausea.
What this interaction means in plain words
Cimetidine and Estrogens esterified have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cimetidine weakly inhibits CYP3A4-mediated estrogen metabolism.
What to do
No routine adjustment is needed; reassess if estrogenic adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cimetidine and Estrogens esterified, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Estrogens esterified?
MediHelp rates the interaction as minor. Cimetidine and Estrogens esterified have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens are partly metabolized by CYP3A4, so cimetidine may slightly raise estrogen levels. Clinical impact is typically small and may show as breast tenderness or nausea.
How serious is the interaction between Cimetidine and Estrogens esterified?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess if estrogenic adverse effects appear.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
