Drug interactions
Cimetidine + Glibenclamide
Severity: Moderate
Cimetidine and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may enhance the hypoglycemic effect of glyburide in some patients. The effect is variable and usually modest.
What this interaction means in plain words
Cimetidine and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Glibenclamide belongs to Endocrine.
Why it happens
Cimetidine inhibits hepatic metabolism of glyburide, with possible contribution from altered absorption.
What to do
Monitor blood glucose when cimetidine is started or stopped and reduce the glyburide dose if hypoglycemia occurs. Famotidine is an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Cimetidine with Glibenclamide?
MediHelp rates the interaction as moderate. Cimetidine and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may enhance the hypoglycemic effect of glyburide in some patients. The effect is variable and usually modest.
How serious is the interaction between Cimetidine and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when cimetidine is started or stopped and reduce the glyburide dose if hypoglycemia occurs. Famotidine is an alternative.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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