Drug interactions
Cimetidine + Glimepiride-pioglitazone
Severity: Minor
Cimetidine and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a nonspecific CYP inhibitor and may modestly increase pioglitazone and glimepiride exposure. Clinical significance is usually small.
What this interaction means in plain words
Cimetidine and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Weak inhibition of CYP-mediated metabolism by cimetidine.
What to do
Monitor blood glucose when starting or stopping cimetidine; consider famotidine as an alternative.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Cimetidine and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine is a nonspecific CYP inhibitor and may modestly increase pioglitazone and glimepiride exposure. Clinical significance is usually small.
How serious is the interaction between Cimetidine and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping cimetidine; consider famotidine as an alternative.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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