Drug interactions
Cimetidine + Hydroxyprogesterone caproate
Severity: Minor
Cimetidine and Hydroxyprogesterone caproate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may increase hydroxyprogesterone caproate exposure. Clinical significance is likely minimal given the drug's depot administration and tolerability.
What this interaction means in plain words
Cimetidine and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cimetidine inhibits CYP3A4, which contributes to the metabolism of hydroxyprogesterone caproate.
What to do
No action is needed beyond routine monitoring for progestogen adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Hydroxyprogesterone caproate?
MediHelp rates the interaction as minor. Cimetidine and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may increase hydroxyprogesterone caproate exposure. Clinical significance is likely minimal given the drug's depot administration and tolerability.
How serious is the interaction between Cimetidine and Hydroxyprogesterone caproate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond routine monitoring for progestogen adverse effects.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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