Drug interactions
Cimetidine + Infigratinib
Severity: Moderate
Cimetidine and Infigratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib has pH-dependent solubility, so acid suppression can reduce its absorption and efficacy. Cimetidine raises gastric pH and may therefore lower infigratinib exposure.
What this interaction means in plain words
Cimetidine and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Elevated gastric pH reduces the dissolution and absorption of infigratinib.
What to do
Avoid if possible; otherwise take infigratinib at least 2 hours before or 10 hours after the H2 antagonist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Infigratinib?
MediHelp rates the interaction as moderate. Cimetidine and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Infigratinib has pH-dependent solubility, so acid suppression can reduce its absorption and efficacy. Cimetidine raises gastric pH and may therefore lower infigratinib exposure.
How serious is the interaction between Cimetidine and Infigratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise take infigratinib at least 2 hours before or 10 hours after the H2 antagonist.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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