Drug interactions
Cimetidine + Isradipine
Severity: Moderate
Cimetidine and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine can increase isradipine plasma concentrations, which may intensify hypotension, flushing, headache and edema. The effect is typically modest but can matter at the start or end of cimetidine therapy.
What this interaction means in plain words
Cimetidine and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cimetidine inhibits CYP3A4 and reduces hepatic blood flow, decreasing first-pass metabolism of isradipine.
What to do
Monitor blood pressure and heart rate when starting or stopping cimetidine and reduce the isradipine dose if hypotension occurs; consider famotidine as an alternative acid suppressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Isradipine?
MediHelp rates the interaction as moderate. Cimetidine and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine can increase isradipine plasma concentrations, which may intensify hypotension, flushing, headache and edema. The effect is typically modest but can matter at the start or end of cimetidine therapy.
How serious is the interaction between Cimetidine and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping cimetidine and reduce the isradipine dose if hypotension occurs; consider famotidine as an alternative acid suppressant.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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