Drug interactions
Cimetidine + Ixabepilone
Severity: Moderate
Cimetidine and Ixabepilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may increase ixabepilone exposure, which could worsen neutropenia and peripheral neuropathy.
What this interaction means in plain words
Cimetidine and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cimetidine inhibits CYP3A4, the main enzyme metabolizing ixabepilone.
What to do
Use famotidine or another non-inhibiting agent instead. If combined, monitor blood counts and neuropathy and consider dose reduction of ixabepilone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Ixabepilone?
MediHelp rates the interaction as moderate. Cimetidine and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may increase ixabepilone exposure, which could worsen neutropenia and peripheral neuropathy.
How serious is the interaction between Cimetidine and Ixabepilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use famotidine or another non-inhibiting agent instead. If combined, monitor blood counts and neuropathy and consider dose reduction of ixabepilone.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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