Drug interactions
Cimetidine + Paclitaxel protein bound
Severity: Minor
Cimetidine and Paclitaxel protein bound: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is metabolized by CYP2C8 and CYP3A4, and cimetidine is a weak CYP3A4 inhibitor, so exposure could rise slightly. Increased toxicity such as neutropenia or neuropathy is possible but not well documented.
What this interaction means in plain words
Cimetidine and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by cimetidine may slow paclitaxel metabolism.
What to do
No empirical dose change; monitor blood counts and neuropathy as per standard paclitaxel care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Paclitaxel protein bound?
MediHelp rates the interaction as minor. Cimetidine and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel is metabolized by CYP2C8 and CYP3A4, and cimetidine is a weak CYP3A4 inhibitor, so exposure could rise slightly. Increased toxicity such as neutropenia or neuropathy is possible but not well documented.
How serious is the interaction between Cimetidine and Paclitaxel protein bound?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change; monitor blood counts and neuropathy as per standard paclitaxel care.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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