Drug interactions
Cimetidine + Papaveretum
Severity: Moderate
Cimetidine and Papaveretum: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains morphine, whose effects may be modestly increased by cimetidine. Respiratory depression and sedation are the main concerns.
What this interaction means in plain words
Cimetidine and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cimetidine inhibition of hepatic metabolism may reduce clearance of the opium alkaloids.
What to do
Monitor respiratory rate and sedation, and reduce the opioid dose if excessive effects occur. Consider famotidine as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Papaveretum?
MediHelp rates the interaction as moderate. Cimetidine and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum contains morphine, whose effects may be modestly increased by cimetidine. Respiratory depression and sedation are the main concerns.
How serious is the interaction between Cimetidine and Papaveretum?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and sedation, and reduce the opioid dose if excessive effects occur. Consider famotidine as an alternative.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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