Drug interactions
Cimetidine + Parecoxib
Severity: Minor
Cimetidine and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, which is cleared by CYP3A4 and CYP2C9, and cimetidine may modestly raise valdecoxib levels. The increase is small and seldom of clinical consequence.
What this interaction means in plain words
Cimetidine and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cimetidine inhibits CYP3A4 and CYP2C9 metabolism of valdecoxib.
What to do
No routine adjustment is needed; monitor for NSAID adverse effects such as hypertension, edema or gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Parecoxib?
MediHelp rates the interaction as minor. Cimetidine and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib is converted to valdecoxib, which is cleared by CYP3A4 and CYP2C9, and cimetidine may modestly raise valdecoxib levels. The increase is small and seldom of clinical consequence.
How serious is the interaction between Cimetidine and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for NSAID adverse effects such as hypertension, edema or gastrointestinal upset.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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