Drug interactions
Cimetidine + Ponatinib
Severity: Minor
Cimetidine and Ponatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib solubility is pH dependent, but clinical studies with a strong acid suppressant showed little effect on exposure. Any interaction is likely small.
What this interaction means in plain words
Cimetidine and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Ponatinib belongs to Oncology.
Why it happens
Higher gastric pH may modestly reduce ponatinib dissolution.
What to do
No dose change is required; monitor treatment response as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Ponatinib
Frequently asked questions
Can I take Cimetidine with Ponatinib?
MediHelp rates the interaction as minor. Cimetidine and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ponatinib solubility is pH dependent, but clinical studies with a strong acid suppressant showed little effect on exposure. Any interaction is likely small.
How serious is the interaction between Cimetidine and Ponatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required; monitor treatment response as routine.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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