Drug interactions
Cimetidine + Tenofovir disoproxil
Severity: Minor
Cimetidine and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine competes for renal tubular secretion and may modestly raise tenofovir concentrations. The increase is generally small, and the clinical effect is typically limited in patients with normal renal function.
What this interaction means in plain words
Cimetidine and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for active tubular secretion via organic cation and anion transporters.
What to do
No routine dose adjustment is needed. Monitor renal function periodically, especially in patients with existing renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Cimetidine and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine competes for renal tubular secretion and may modestly raise tenofovir concentrations. The increase is generally small, and the clinical effect is typically limited in patients with normal renal function.
How serious is the interaction between Cimetidine and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Monitor renal function periodically, especially in patients with existing renal impairment.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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