Drug interactions
Cimetidine + Triazolam
Severity: Moderate
Cimetidine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine inhibits CYP3A4 and can raise triazolam concentrations, prolonging and intensifying sedation, psychomotor impairment and amnesia. Risk is higher in elderly patients.
What this interaction means in plain words
Cimetidine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cimetidine inhibits CYP3A4-mediated oxidative metabolism of triazolam, decreasing its clearance.
What to do
Consider using a lower triazolam dose or switch to an H2 blocker without CYP inhibition such as famotidine; monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Triazolam?
MediHelp rates the interaction as moderate. Cimetidine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine inhibits CYP3A4 and can raise triazolam concentrations, prolonging and intensifying sedation, psychomotor impairment and amnesia. Risk is higher in elderly patients.
How serious is the interaction between Cimetidine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider using a lower triazolam dose or switch to an H2 blocker without CYP inhibition such as famotidine; monitor for excessive sedation.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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