Drug interactions
Cimetidine + Vincristine liposomal
Severity: Moderate
Cimetidine and Vincristine liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a CYP3A4 inhibitor and could raise exposure to vincristine, which is cleared mainly by CYP3A. Higher vincristine levels may worsen neurotoxicity, including peripheral neuropathy and constipation or ileus. Clinical data with the liposomal formulation are limited and the effect is mostly predicted.
What this interaction means in plain words
Cimetidine and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cimetidine inhibits hepatic and intestinal CYP3A4, potentially reducing vincristine metabolism.
What to do
Monitor for signs of vincristine neurotoxicity and bowel dysfunction. Consider an H2 blocker with less CYP inhibition, such as famotidine, if acid suppression is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cimetidine and Vincristine liposomal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Cimetidine with Vincristine liposomal?
MediHelp rates the interaction as moderate. Cimetidine and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine is a CYP3A4 inhibitor and could raise exposure to vincristine, which is cleared mainly by CYP3A. Higher vincristine levels may worsen neurotoxicity, including peripheral neuropathy and constipation or ileus. Clinical data with the liposomal formulation are limited and the effect is mostly predicted.
How serious is the interaction between Cimetidine and Vincristine liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of vincristine neurotoxicity and bowel dysfunction. Consider an H2 blocker with less CYP inhibition, such as famotidine, if acid suppression is needed.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
