Drug interactions
Cimetidine + Zolpidem
Severity: Minor
Cimetidine and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may modestly raise zolpidem concentrations, but studies have shown no significant clinical or pharmacodynamic changes. Slightly increased sedation is possible in susceptible patients.
What this interaction means in plain words
Cimetidine and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Zolpidem belongs to Central Nervous System.
Why it happens
Cimetidine inhibits CYP3A4 and other CYPs involved in zolpidem metabolism.
What to do
No routine dose change is needed. Counsel on next-day drowsiness, particularly in elderly patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Zolpidem
Frequently asked questions
Can I take Cimetidine with Zolpidem?
MediHelp rates the interaction as minor. Cimetidine and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may modestly raise zolpidem concentrations, but studies have shown no significant clinical or pharmacodynamic changes. Slightly increased sedation is possible in susceptible patients.
How serious is the interaction between Cimetidine and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Counsel on next-day drowsiness, particularly in elderly patients.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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