Drug interactions
Cinnamon + Diflunisal
Severity: Minor
Cinnamon and Diflunisal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnamon, particularly cassia containing coumarin, is theoretically able to add to the bleeding tendency of NSAIDs. Clinical evidence of a meaningful interaction is lacking.
What this interaction means in plain words
Cinnamon and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive effect on hemostasis; coumarin content of cassia cinnamon may have weak anticoagulant activity.
What to do
No routine action is needed for culinary amounts. Ask patients taking high-dose cinnamon supplements with diflunisal to report unusual bruising or bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Cinnamon with Diflunisal?
MediHelp rates the interaction as minor. Cinnamon and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cinnamon, particularly cassia containing coumarin, is theoretically able to add to the bleeding tendency of NSAIDs. Clinical evidence of a meaningful interaction is lacking.
How serious is the interaction between Cinnamon and Diflunisal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed for culinary amounts. Ask patients taking high-dose cinnamon supplements with diflunisal to report unusual bruising or bleeding.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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