Drug interactions
Cinnamon + Tolbutamide
Severity: Minor
Cinnamon and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnamon may modestly lower blood glucose and could add to the effect of tolbutamide. Clinically significant hypoglycemia is possible but not well documented.
What this interaction means in plain words
Cinnamon and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive glucose-lowering effect from improved insulin sensitivity.
What to do
Monitor blood glucose if the patient takes cinnamon supplements regularly. Adjust tolbutamide only if glucose falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Cinnamon with Tolbutamide?
MediHelp rates the interaction as minor. Cinnamon and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cinnamon may modestly lower blood glucose and could add to the effect of tolbutamide. Clinically significant hypoglycemia is possible but not well documented.
How serious is the interaction between Cinnamon and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if the patient takes cinnamon supplements regularly. Adjust tolbutamide only if glucose falls.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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