Drug interactions
Ciprofibrate + Tolazamide
Severity: Moderate
Ciprofibrate and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates can improve insulin sensitivity and may enhance the effect of sulfonylureas, increasing the risk of hypoglycemia. Protein-binding displacement may contribute, especially with low albumin.
What this interaction means in plain words
Ciprofibrate and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose lowering through improved insulin sensitivity, with possible protein-binding displacement.
What to do
Monitor blood glucose when ciprofibrate is started. Reduce the tolazamide dose if hypoglycemia occurs, particularly in patients with low albumin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Ciprofibrate with Tolazamide?
MediHelp rates the interaction as moderate. Ciprofibrate and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates can improve insulin sensitivity and may enhance the effect of sulfonylureas, increasing the risk of hypoglycemia. Protein-binding displacement may contribute, especially with low albumin.
How serious is the interaction between Ciprofibrate and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ciprofibrate is started. Reduce the tolazamide dose if hypoglycemia occurs, particularly in patients with low albumin.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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