Drug interactions
Ciprofloxacin + Dichlorphenamide
Severity: Moderate
Ciprofloxacin and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide commonly causes hypokalemia and metabolic acidosis, both of which increase susceptibility to QT prolongation and arrhythmia. Ciprofloxacin has a modest QT effect, so the combination may raise arrhythmia risk if potassium is low.
What this interaction means in plain words
Ciprofloxacin and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Carbonic anhydrase inhibition causes renal potassium loss, and the resulting hypokalemia potentiates the repolarization effects of ciprofloxacin.
What to do
Measure serum potassium and bicarbonate before and during co-therapy and replace potassium as needed. Consider an ECG if other QT-prolonging drugs or cardiac disease are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Ciprofloxacin with Dichlorphenamide?
MediHelp rates the interaction as moderate. Ciprofloxacin and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide commonly causes hypokalemia and metabolic acidosis, both of which increase susceptibility to QT prolongation and arrhythmia. Ciprofloxacin has a modest QT effect, so the combination may raise arrhythmia risk if potassium is low.
How serious is the interaction between Ciprofloxacin and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium and bicarbonate before and during co-therapy and replace potassium as needed. Consider an ECG if other QT-prolonging drugs or cardiac disease are present.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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