Drug interactions
Ciprofloxacin + Dienogest / estradiol valerate
Severity: Minor
Ciprofloxacin and Dienogest / estradiol valerate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been proposed to reduce hormone levels through effects on gut flora, but for ciprofloxacin there is no good evidence of reduced contraceptive efficacy. Any risk is considered very low.
What this interaction means in plain words
Ciprofloxacin and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Hypothesized reduction of enterohepatic recycling of estrogen through altered gut flora; not established for ciprofloxacin.
What to do
No routine action is needed. Advise patients to use additional contraception if vomiting or severe diarrhea occurs during illness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Dienogest / estradiol valerate?
MediHelp rates the interaction as minor. Ciprofloxacin and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been proposed to reduce hormone levels through effects on gut flora, but for ciprofloxacin there is no good evidence of reduced contraceptive efficacy. Any risk is considered very low.
How serious is the interaction between Ciprofloxacin and Dienogest / estradiol valerate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Advise patients to use additional contraception if vomiting or severe diarrhea occurs during illness.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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