Drug interactions
Ciprofloxacin + Gemtuzumab
Severity: Moderate
Ciprofloxacin and Gemtuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin carries a QT prolongation warning, and ciprofloxacin can also modestly prolong the QT interval. Using them together may increase the risk of arrhythmia, especially in patients with electrolyte disturbances or heart disease.
What this interaction means in plain words
Ciprofloxacin and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT interval prolongation through pharmacodynamic effects on cardiac repolarisation.
What to do
Check ECG and electrolytes before and during treatment, correcting hypokalaemia and hypomagnesaemia. Consider a non-QT-prolonging antibiotic if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Ciprofloxacin with Gemtuzumab?
MediHelp rates the interaction as moderate. Ciprofloxacin and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin carries a QT prolongation warning, and ciprofloxacin can also modestly prolong the QT interval. Using them together may increase the risk of arrhythmia, especially in patients with electrolyte disturbances or heart disease.
How serious is the interaction between Ciprofloxacin and Gemtuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before and during treatment, correcting hypokalaemia and hypomagnesaemia. Consider a non-QT-prolonging antibiotic if the patient has other QT risk factors.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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